Curcumin Elevates TFH Cells and Germinal Center B Cell Response for Antibody Production in Mice
نویسندگان
چکیده
منابع مشابه
The LRF transcription factor regulates mature B cell development and the germinal center response in mice.
B cells play a central role in immune system function. Deregulation of normal B cell maturation can lead to the development of autoimmune syndromes as well as B cell malignancies. Elucidation of the molecular features of normal B cell development is important for the development of new target therapies for autoimmune diseases and B cell malignancies. Employing B cell-specific conditional knocko...
متن کاملDifferentiation of germinal center B cells into plasma cells is initiated by high-affinity antigen and completed by Tfh cells
Plasma cells (PCs) derived from germinal centers (GCs) secrete the high-affinity antibodies required for long-term serological immunity. Nevertheless, the process whereby GC B cells differentiate into PCs is uncharacterized, and the mechanism underlying the selective PC differentiation of only high-affinity GC B cells remains unknown. In this study, we show that differentiation into PCs is indu...
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Adaptation of antibody-mediated immunity occurs in germinal centers (GC). It is where affinity maturation, class switching, memory and plasma cell differentiation synergize to generate specific high affinity antibodies that help both to clear and protect against reinfection of invading pathogens. Within GCs, light and dark zone are two compartments instrumental in regulating this process, by se...
متن کاملThe germinal center antibody response in health and disease
The germinal center response is the delayed but sustained phase of the antibody response that is responsible for producing high-affinity antibodies of the IgG, IgA and/or IgE isotypes. B cells in the germinal center undergo re-iterative cycles of somatic hypermutation of immunoglobulin gene variable regions, clonal expansion, and Darwinian selection for cells expressing higher-affinity antibody...
متن کاملGerminal Center B Cell Depletion Diminishes CD4+ Follicular T Helper Cells in Autoimmune Mice
BACKGROUND Continuous support from follicular CD4(+) T helper (Tfh) cells drives germinal center (GC) responses, which last for several weeks to produce high affinity memory B cells and plasma cells. In autoimmune Sle1 and NZB/W F1 mice, elevated numbers of Tfh cells persist, promoting the expansion of self-reactive B cells. Expansion of circulating Tfh like cells have also been described in se...
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ژورنال
عنوان ژورنال: Immune Network
سال: 2019
ISSN: 1598-2629,2092-6685
DOI: 10.4110/in.2019.19.e35